Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute
Descrição
The goal of this project is to elucidate the molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease (NPC). We will investigate the role of protease BACE1, the key Alzheimer's disease (AD) enzyme, in the pathogenesis of NPC disease. We hope that our findings will elucidate BACE1 as a novel target for treating/ameliorating NPC disease.
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://d3i71xaburhd42.cloudfront.net/a0f1920c418c78a80fac7263956cb690794a18da/6-Figure4-1.png)
PDF] Efficient Investigation and Differential Diagnosis of
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.researchgate.net/publication/373912312/figure/fig1/AS:11431281188610757@1694705633038/Common-features-and-differences-between-Alzheimers-disease-and-Niemann-Pick-type-C_Q320.jpg)
PDF) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in
Involvement of the Choroid Plexus in the Pathogenesis of Niemann
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://onlinelibrary.wiley.com/cms/asset/cb4188d2-a449-4117-93fc-397140fe7a12/jnc14895-fig-0003-m.jpg)
Niemann–Pick type C disease: cellular pathology and
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.researchgate.net/publication/372646264/figure/fig2/AS:11431281177138252@1690379169343/Distribution-of-selected-words-which-best-describe-science-before-and-after-the_Q320.jpg)
Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.researchgate.net/publication/356921241/figure/fig3/AS:1099518464532486@1639157038339/Colocalization-of-Vps35-positive-vesicles-and-APP-CT-is-increased-in-NPC1-null-cells-A_Q320.jpg)
PDF) Impaired Retromer Function in Niemann-Pick Type C Disease Is
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.irb.hr/var/ezflow_site/storage/images/media/multimedija-i-datoteke/zmm/lmnf/slide12/590974-1-eng-GB/Slide1_i1200.jpg)
Our research - Ruđer Bošković Institute
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.asbmb.org/getmedia/ad306659-e41e-461d-9417-e84185ed34fd/npc-figure-thumb.jpg?width=480&height=270&ext=.jpg)
From genes to hope
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.irb.hr/var/ezflow_site/storage/images/istrazivanja/zavodi-i-centri/zavod-za-molekularnu-medicinu/laboratorij-za-molekularnu-neurofarmakologiju/projekti/uloga-disfunkcije-lizosoma-u-nastanku-neurodegenerativnih-bolesti/254198-33-cro-HR/Uloga-disfunkcije-lizosoma-u-nastanku-neurodegenerativnih-bolesti.jpg)
Lysosomal dysfunction as a common mechanism of neurodegenerative
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://i1.rgstatic.net/publication/374733060_Overlapping_Neuroimmune_Mechanisms_and_Therapeutic_Targets_in_Neurodegenerative_Disorders/links/652be0710e4a1710e50d1176/largepreview.png)
PDF) Overlapping Neuroimmune Mechanisms and Therapeutic Targets in
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.researchgate.net/publication/372646264/figure/fig1/AS:11431281177157652@1690379169054/Data-comparison-with-other-intervention-and-age-groups-6-th-graders-were-the-most-active_Q320.jpg)
Marko KOSICEK, PhD, Ruđer Bošković Institute, Zagreb
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://i1.rgstatic.net/publication/322710157_N-glycome_of_the_lysosomal_glycocalyx_is_altered_in_Niemann-Pick_Type_C_disease_model_cells/links/5a7172e00f7e9ba2e1cb5e94/largepreview.png)
PDF) N-glycome of the lysosomal glycocalyx is altered in Niemann
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://media.springernature.com/lw685/springer-static/image/art%3A10.1186%2Fs13024-022-00524-0/MediaObjects/13024_2022_524_Fig2_HTML.png)
Solving neurodegeneration: common mechanisms and strategies for
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://www.researchgate.net/publication/355342291/figure/fig4/AS:1079517900734475@1634388532786/NPC1--mice-contain-larger-and-less-CSF-extracellular-vesicles-EVs-A-Average_Q320.jpg)
PDF) Involvement of the Choroid Plexus in the Pathogenesis of
![Molecular mechanism(s) of neurodegeneration in Niemann-Pick type C disease - Ruđer Bošković Institute](https://d3i71xaburhd42.cloudfront.net/55f85a9e4b95b2b7808ce64be21e079f5e16bcbd/4-Figure3-1.png)
PDF] Molecular mechanisms of neurodegeneration in Alzheimer's
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por adulto (o preço varia de acordo com o tamanho do grupo)