2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
Descrição
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://europepmc.org/articles/PMC4424151/bin/gr2_lrg.jpg)
Innate immune restriction and antagonism of viral RNA lacking 2׳-O methylation. - Abstract - Europe PMC
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.biorxiv.org/content/biorxiv/early/2020/03/06/2020.03.05.980045/F2.large.jpg)
The mRNA cap 2'O methyltransferase CMTR1 regulates the expression of certain interferon-stimulated genes
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.pnas.org/cms/10.1073/pnas.1612444114/asset/ebf56a7d-761a-460e-9a6d-50ac895f1676/assets/graphic/pnas.1612444114sfig01.jpeg)
Structure of human IFIT1 with capped RNA reveals adaptable mRNA binding and mechanisms for sensing N1 and N2 ribose 2′-O methylations
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnature09489/MediaObjects/41586_2010_Article_BFnature09489_Fig1_HTML.jpg)
2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.biorxiv.org/content/biorxiv/early/2022/02/03/2022.02.03.478939/F2.large.jpg)
2'-O-methylation of the second transcribed nucleotide within mRNA 5' cap impacts protein production level in a cell specific manner and contributes to RNA immune evasion
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://onlinelibrary.wiley.com/cms/asset/5440b2f0-3d9d-4e88-a775-809835130dcc/bies202200198-fig-0001-m.jpg)
The cap epitranscriptome: Early directions to a complex life as mRNA - Anreiter - 2023 - BioEssays - Wiley Online Library
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fnri3344/MediaObjects/41577_2013_Article_BFnri3344_Fig1_HTML.jpg)
The broad-spectrum antiviral functions of IFIT and IFITM proteins
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://www.pnas.org/cms/10.1073/pnas.2100170118/asset/84590f89-32b1-451b-a564-31bd12e2c4d5/assets/images/large/pnas.2100170118fig04.jpg)
2′-O methylation of RNA cap in SARS-CoV-2 captured by serial crystallography
![2′-O methylation of the viral mRNA cap evades host restriction by IFIT family members](https://europepmc.org/articles/PMC4234691/bin/gr2_lrg.jpg)
IFIT1: A dual sensor and effector molecule that detects non-2'-O methylated viral RNA and inhibits its translation. - Abstract - Europe PMC
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