Toxins, Free Full-Text
Descrição
L-Amino acid oxidase (LAAO) is an enzyme found in snake venom that has multifaceted effects, including the generation of hydrogen peroxide (H2O2) during oxidative reactions, leading to various biological and pharmacological outcomes such as apoptosis, cytotoxicity, modulation of platelet aggregation, hemorrhage, and neutrophil activation. Human neutrophils respond to LAAO by enhancing chemotaxis, and phagocytosis, and releasing reactive oxygen species (ROS) and pro-inflammatory mediators. Exosomes cellular nanovesicles play vital roles in intercellular communication, including immune responses. This study investigates the impact of Calloselasma rhodostoma snake venom-derived LAAO (Cr-LAAO) on human neutrophil exosome release, including activation patterns, exosome formation, and content. Neutrophils isolated from healthy donors were stimulated with Cr-LAAO (100 μg/mL) for 3 h, followed by exosome isolation and analysis. Results show that Cr-LAAO induces the release of exosomes with distinct protein content compared to the negative control. Proteomic analysis reveals proteins related to the regulation of immune responses and blood coagulation. This study uncovers Cr-LAAO’s ability to activate human neutrophils, leading to exosome release and facilitating intercellular communication, offering insights into potential therapeutic approaches for inflammatory and immunological disorders.
Multiplex Immunoassays with Quantum Dots. A. Schematic of the 4-color
Pure Haven Essentials by Heather Jimenez
Industrial Hygiene Consultants
The Ultimate Non-Toxic & Chemical Free Mattress Guide - Amerisleep
Slim Organix - Cleanse -Extreme Cleanse Master Blend- Flush Excess Waste and Toxins- Increase Nutrient Absorption- Promote Weight Loss -100% Natural Key Ingredients
Spread Love Not Toxins SVG Yas Queen PNG Social Distancing
Just How Toxic Are All the Manmade Chemicals in Our Bodies?
Toxic Free Food : Toxic-Free Food
Jane Long
Staphylococcal enterotoxins in scarlet fever complicating chickenpox. - Abstract - Europe PMC
Socioenvironmental adversity and adolescent psychotic experiences: Exploring potential mechanisms in a UK longitudinal cohort [Schizophrenia Bulletin, Mar 2023 -- free full-text] : r/psychopathology
de
por adulto (o preço varia de acordo com o tamanho do grupo)
