Molecules, Free Full-Text
Descrição
Trying to meet the multitarget-directed ligands strategy, a series of previously described aryl-substituted phenylalanine derivatives, reported as competitive antagonists of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, were screened in vitro for their free-radical scavenging and antioxidant capacity in two different assays: ferric reducing antioxidant power (FRAP) and oxygen radical absorbance capacity fluorescent (ORAC-FL) assays. The most active antioxidants 1 and 8 were further examined to evaluate their neuroprotective properties in vitro. In this study, compound 1 showed a significant neuroprotective effect against the neurotoxin 6-hydroxydopamine in neuroblastoma SH-SY5Y and IMR-32 cell lines. Both compounds also showed prevention from high levels of reactive oxygen species (ROS) in SH-SY5Y cells. Furthermore, the desired monoamine oxidase B (MAO-B) inhibition effect (IC50 = 278 ± 29 nM) for 1 was determined. No toxic effects up to 100 µM of 1 and 8 against neuroblastoma cells were observed. Furthermore, in vivo studies showed that compound 1 demonstrated significant anticonvulsant potential in 6-Hz test, but in neuropathic pain models its antiallodynic and antihyperalgesic properties were not observed. Concluding, the compound 1 seems to be of higher importance as a new phenylalanine-based lead candidate due to its confirmed promise in in vitro and in vivo anticonvulsant activity.
![Molecules, Free Full-Text](https://i.pinimg.com/736x/75/54/c2/7554c2dc9ed086a0996f7c5492ca0054.jpg)
Molecules, Free Full-Text
![Molecules, Free Full-Text](https://i.pinimg.com/564x/18/c7/55/18c75589181d802f3b32392f1954fd57.jpg)
Molecules, Free Full-Text
![Molecules, Free Full-Text](https://i.pinimg.com/736x/df/cd/a2/dfcda2fc0cae71099054aa46861f78f3.jpg)
Molecules, Free Full-Text
![Molecules, Free Full-Text](https://www.mdpi.com/molecules/molecules-05-M130/article_deploy/html/images/molecules-05-M130-i001.png)
Molecules, Free Full-Text
![Molecules, Free Full-Text](https://pub.mdpi-res.com/molecules/molecules-26-02039/article_deploy/html/images/molecules-26-02039-g001-550.jpg?1628043824)
Tuneup 2.7 0.1 Get File - Colaboratory
![Molecules, Free Full-Text](https://i.ytimg.com/vi/BExNxLRCiSo/hqdefault.jpg)
Important Questions for Class 9 Chemistry Chapter 3 Atoms and
![Molecules, Free Full-Text](https://ars.els-cdn.com/content/image/1-s2.0-S0927775723020976-ga1.jpg)
Adsorption of Zwitterionic Oligomer-grafted Silica Nanoparticles
![Molecules, Free Full-Text](https://onlinelibrary.wiley.com/pb-assets/assets/15213773/cover/slide-4-1702911385630.jpg)
Angewandte Chemie International Edition - Wiley Online Library
![Molecules, Free Full-Text](https://media.springernature.com/m685/springer-static/image/art%3A10.1038%2Fs42256-023-00759-6/MediaObjects/42256_2023_759_Fig1_HTML.png)
Multi-modal molecule structure–text model for text-based retrieval
![Molecules, Free Full-Text](https://i.pinimg.com/736x/6c/58/7c/6c587c1ee976fd2bb0bc71bc7a38cbfd.jpg)
Molecules Set of 4 Art PRINTABLES Caffeine Happiness Sleep
![Molecules, Free Full-Text](https://www.mdpi.com/molecules/molecules-05-00985/article_deploy/html/images/molecules-05-00985-i001.png)
Molecules, Free Full-Text
![Molecules, Free Full-Text](https://img.freepik.com/free-vector/modern-molecules-background_1035-8990.jpg)
Free Vector Modern molecules background
![Molecules, Free Full-Text](https://pub.mdpi-res.com/molecules/molecules-29-00012/article_deploy/html/images/molecules-29-00012-g001-550.jpg?1702980533)
Molecules An Open Access Journal from MDPI
![Molecules, Free Full-Text](https://onlinelibrary.wiley.com/cms/asset/c94086f2-ca2a-414e-9d95-38e10c32bec1/anie202315046-toc-0001-m.jpg)
Angewandte Chemie International Edition: Early View
![Molecules, Free Full-Text](https://external-preview.redd.it/N9hM41OF77WCWVihVC_XLwxZgGtRqIcGY69ugCaoCEU.jpg?auto=webp&s=b8e3bf071c79fb09b8da14695097b66fd5f26e36)
Molecules, Free Full-Text
de
por adulto (o preço varia de acordo com o tamanho do grupo)