EB2 pS222 antibody
Descrição
EB2 S222 site is a target for phosphorylation by the CDKL5 protein kinase; loss-of-function mutations in the human CDKL5 gene are associated with CDKL5 Deficiency Disorder, a neurodevelopmental disorder with intractable epilepsy (Baltussen, Negraes, et al
![EB2 pS222 antibody](https://media.springernature.com/lw685/springer-static/image/art%3A10.1038%2Fs41467-023-43475-w/MediaObjects/41467_2023_43475_Fig2_HTML.png)
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
![EB2 pS222 antibody](https://www.covalab.com/media/catalog/product/cache/3e75d17be04cbebee9a78c36b24b6eea/0/0/00117741_2.jpg)
EB2 pS222 antibody
![EB2 pS222 antibody](https://www.covalab.com/media/jetpulp/storeswitcher/modal/store/map-eu.png)
Litterature
![EB2 pS222 antibody](https://www.researchgate.net/publication/364333002/figure/fig5/AS:11431281089951269@1665800172367/flCDKL5-production-with-a-high-copy-number-bicistronic-plasmid-a-Comparison-of-flCDKL5_Q320.jpg)
PDF) Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
![EB2 pS222 antibody](https://dm5migu4zj3pb.cloudfront.net/manuscripts/143000/143655/small/JCI143655.f1.gif)
JCI - Temporal manipulation of Cdkl5 reveals essential postdevelopmental functions and reversible CDKL5 deficiency disorder–related deficits
![EB2 pS222 antibody](https://www.biorxiv.org/content/biorxiv/early/2023/06/16/2023.04.24.538049/F2.large.jpg)
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
![EB2 pS222 antibody](https://pubs.acs.org/cms/10.1021/acschemneuro.3c00135/asset/images/medium/cn3c00135_0012.gif)
Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective
![EB2 pS222 antibody](https://www.biorxiv.org/content/biorxiv/early/2022/11/24/2022.11.24.517538/F8.large.jpg)
Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability
![EB2 pS222 antibody](https://www.covalab.com/media/catalog/product/cache/6b1c09900b407c50fce2db5e66ebc123/0/0/00117741_1_2.jpg)
EB2 pS222 antibody
![EB2 pS222 antibody](https://iiif.elifesciences.org/lax:88206%2Felife-88206-fig6-figsupp1-v2.tif/full/full/0/default.jpg)
Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology
![EB2 pS222 antibody](https://europepmc.org/articles/PMC6293278/bin/EMBJ-37-e99763-g011.jpg)
Chemical genetic identification of CDKL5 substrates reveals its role in neuronal microtubule dynamics. - Abstract - Europe PMC
![EB2 pS222 antibody](https://0.academia-photos.com/270381177/120788601/110116475/s200_marzia.calvanese.png)
PDF) Active human full-length CDKL5 produced in the Antarctic bacterium Pseudoalteromonas haloplanktis TAC125
![EB2 pS222 antibody](http://www.bio-review.com/wp-content/uploads/2022/04/Rockland.jpg)
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